Endocrine Abstracts

Background: Transsphenoidal surgery of pituitary adenoma is often first-line therapy for patients with acromegaly. Pharmacotherapy and/or radiotherapy are applied when surgery fails to achieve good disease control, or when surgery is impossible or contraindicated. In this study, we report the results of therapies, rates of cure and hypophyseal insufficiency in our acromegalic patients.Methods and results: Medical files of the 62 patients who were followe...

Hypothyroidism is a common endocrine disorder which is easily treatable by an appropriate thyroid hormone replacement therapy in the majority of patients. In some patients, hypothyroidism is refractory to oral levothyroxine substitution. Common causes of lack of response to levothyroxine replacement comprise non-compliance and impaired absorption. We report a case of pseudomalabsorption of levothyroxine. Here, we report two female patients with hypothyroidism who had multinod&...

Objective: Nonfunctional adrenal masses are a risk indicator of increased cardiometabolic risk. Especially; increased thrombogenic ambient, insulin resistance, hepatosteatosis and abdominal obesity are determined in these patients with nonfunctional adrenal masses. Our purpose was to show the association of adrenal incidentalome and metabolic syndrome in consideration of the studies and to detect the increase in the carotid intima-media thickness which is regarded as the prece...

Introduction: Primary aldosteronism is presented with signs of hypertension and hypokalaemia classically, however, primary adrenal carcinoma is very rare condition. We aimed to present a patient with a metastatic adrenal carcinoma after the primary diagnosis of hyperaldosteronism.Case report: A 46 years old male patient was referred to our hospital with weakness, dry mouth and weight loss. He had lost weight as 31 pounds during last 3 months. Physical ex...

Introduction: Acromegaly is a very rare disease with persistent GH secretion due to excessive release of liver IGF1. The risk of malignancy, particularly colon cancer, is increased in acromegalic patients. But no evidence is found in the literature associated increasing of laryngeal carcinoma in acromegalic patients. We aimed to present this case that laryngeal carcinoma should be considered in acromegaly by the clinicians.Case report: A 51-year-old male...

Background: Acromegaly is a relatively rare endocrine disorder which may result in morbidity and mortality. In this study, we report the demographical and clinical characteristics of 62 acromegalic patients who were followed-up at our Department of Endocrinology Clinic.Methods and results: In this retro-prospective study, medical files of the patients who were followed-up from 1984 to 2013 were examined. Data was obtained for age at the time of diagnosis...

Purpose: Most of the acromegaly cases are due to agrowth hormone-secreting pituitary adenomas of which immunohistochemical subtype seperated as sparsely granulated adenoma (SGA) and densely granulated adenoma (DGA). SGA’s were reported to have more aggressive clinical course and therapy resistance. We investigated our patients for these aspects.Method: Forty (F21, M19) patients with acromegaly who diagnosed and operated for pituitary adenoma at our...

Purpose: Diabetic Foot Ulceration (DFU) is common problem throughout the world and resulting in major economic consequences for the patients and country. We aim to describe estimated cost of illness between patients with DFU in southern Turkey.Methods: A total of 148 (F = 55, M = 93) patients with DFU were included in this retrospective study. We also included more than one admission of the patients with DFU. Patients characteri...

Objective: Hereditary pituitary adenomas (PAs) are rare and occur either isolated or as part of a syndrome. Familial isolated pituitary adenoma (FIPA) is the presence of only PA in at least two members of a family, where “Aryl hydrocarbon receptor interacting protein-AIP” gene mutations have been identified in 10-20% of cases. However, the cause of tumorigenesis in the majority is unknown. We aimed to identify novel genetic variants in a cohort of FIPA patie...

Purpose: To evaluate the relationship between basal dehydroepiandrosterone-sulfate (DHEA-S) levels and other tests used in the diagnosis and differential diagnosis of Cushing’s Syndrome (CS) among the patients with pathologically confirmed CS.Methods: In this multicenter study, the data of 623 patients with CS were evaluated retrospectively. The patients were classified as Group 1 (n = 353 Cushing’s disease;CD), Group 2 (n</e...